![]() ![]() Phaeochromocytoma (used only with an alpha-receptor blocking drug): If necessary, the dose may be increased incrementally to a maximum of 160mg twice daily. Dosage should begin with 40mg twice daily, increasing to 80mg twice daily depending on heart rate response. In order to improve compliance, the total daily dosage may thereafter be given as 80mg twice a day.ĭosage should be titrated to achieve approximately 25% reduction in resting heart rate. Treatment should start between days 5 and 21 after myocardial infarction, with an initial dose of 40mg four times a day for two or three days. ![]() Patients should be reviewed after six to twelve months' treatment.Īrrhythmias, anxiety tachycardia, hypertrophic obstructive cardiomyopathy and thyrotoxicosis:Ī dosage range of 10 to 40mg three or four times a day usually achieves the required response. Treatment should be continued according to response. ![]() Generalised anxiety, requiring longer term therapy, usually responds adequately to 40mg twice daily which, in individual cases, may be increased to 40mg three times daily. An adequate response in migraine and essential tremor is usually seen in the range 80 to 160mg/day and in angina in the reane120 to 240mg/day.Ī dose of 40mg daily may provide short term relief of acute situational anxiety. With concurrent diuretic or other antihypertensive drugs a further reduction of blood pressure is obtained.Ī starting dose of 40mg two or three times daily may be increased by the same amount at weekly intervals according to response. The usual dose range is 160 to 320mg per day. Date of first authorisation/renewal of the authorisationĪ starting dose of 80mg twice a day may be increased at weekly intervals according to response.
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